Moyowosi Game Reserve was gazetted in 1981.
It is situated in Kigoma Region in the western part of Tanzania and covers an area of 6000 km² lying on the edge of the great central plateau between the East and western Rift Valley arms, with an altitude ranging from 800m to 1600m.
The reserve is recognized by supporting large populations of buffalo, Topi, Lion, Giraffe, Zebra, Hartebeest, Roan antelope, Greater kudu Waterbuck Sitatunga, Hippo and the Crocodile. Bird species found in the reserve include wattled crane and Shoebill stock.
The reserve can be accessed by chartered light aircraft, scheduled flight, road using Four wheel and train.